Queen of the South duo Sean O'Connor and Andy Aitken are minor fitness doubts but both should feature.
O'Connor, who has missed two games with a neck injury, will be competing with on-loan John Stewart to partner top-scorer Stephen Dobbie up front.
Aberdeen manager Jimmy Calderwood must continue without injured trio Jamie Smith, Lee Mair and Richie Byrne.
Steve Lovell and Derek Young are fit again but may have to be content with a place on the bench.
Jackie McNamara has recovered from the knock he suffered in Monday's Premier League victory over Falkirk.
Queens midfielder Neil Scally misses out due to a knee ligament injury.
Former Celtic defender Craig Reid and on-loan Kilmarnock forward Robert Campbell are both cup-tied for the First Division side.
Queen of the South (from): McDonald, McCann, Thomson, Aitken, Harris, Burns
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