Gordon Strachan's side travel to Dundee United, while Rangers visit Aberdeen.
Both Old Firm sides are locked on 86 points, with Celtic's goal difference four better off than their rivals.
Celtic captain Stephen McManus wants to win the title in memory of late coach Tommy Burns, while Gers boss Walter Smith has no regrets over the campaign.
Gordon Strachan is trying to steer Celtic to their third consecutive SPL crown, while Smith wants to add the title to the CIS Cup - with the Scottish Cup final against Queen of the South still to be played on Saturday and his side having also reached the Uefa Cup final, where they lost to Zenit St Petersburg.
The destination of the title will be decided at Tannadice and Pittodrie.
A win for both Old Firm clubs will see the title decided on goal difference.
Rangers triumphed on the final day of the season in 2003 and 2005 but Celtic's McManus is determined his side will be celebrating their third title in as many years.
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